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Ranitidine (Zantac)

INDICATION

A medication used for the treatment of ulcers and gastritis. Also effective for the treatment of reflux oesophagitis.

SIDE EFFECTS

Decreased blood platelets, headache, dizziness, confusion, nausea, vomiting, constipation, decreased heart rate, heart palpitations, jaundice, elevated liver enzymes, and rash.

INTERACTIONS and PRECAUTIONS

  1. Separate from doses of antacids by 1 hour, to avoid absorption problems of ranitidine.
  2. Use with glipizide may increase glipizide effect.
  3. Use with ketoconazole may decrease ranitidine absorption.
  4. Use with procainamide can increase procainamide effect and toxicity.
  5. Use with tamoxifen can decrease tamoxifen levels.
  6. Use with theophylline may increase theophylline effect.
  7. Use with anticoagulants (Warfarin) may increase anticoagulant effect.
  8. Use with alcohol can reduce ranitidine effect.
  9. Use with nicotine can reduce ranitidine effect.
  10. Use with vitamin B12 can reduce vitamin B12 absorption.

USUAL DOSE

Adults: oral, 150 mg twice a day; or 300 mg once a day (bedtime).

Paediatrics: individualised dosing.

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