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Phenylbutazone NSAIDs

(BRITISH) UK Trade name products: (Butacote)

(AMERICAN) US Trade name products which contain phenylbutazone include: (Azolid) (Butazolodin) (Butazone) (Alka-Butazolidin) (Alka-Phenylbutazone) (Alkabutazone) (Apo-Phenylbutazone) (Butatab) (Intrabutazone) (Novobutazone)(Phenylone Plus)

INDICATION

A treatment used to relieve pain, fever, and inflammation.

SIDE EFFECTS

Anaemia, decreased white blood cells and blood platelets, confusion, agitation, high blood pressure, pericarditis, myocarditis, blurred vision, hearing loss, retinal detachment, swelling, nausea, vomiting, diarrhoea, ulcers, kidney failure, bloody urine, hepatitis, high blood sugar, thyroid goiter, itching, spots, blisters, and rashes.

INTERACTIONS and PRECAUTIONS

  1. Separate from the ingestion of cholestyramine by 1 hour.
  2. Insulin and oral hypoglycaemic agents may lower blood sugar more, when taken with this medication.
  3. Anticoagulant medications (warfarin) can increase the risk of bleeding.
  4. Phenytoin and lithium can have elevated plasma levels, which could lead to their toxicity
  5. Use with ACE inhibitors (captopril, lisinopril, enalapril) can result in decreased ACE inhibitor effect.
  6. Use with aspirin or alcohol can promote stomach ulcers or bleeding.
  7. Use with beta-blockers (propranolol, metoprolol, labetalol, carteolol) can decrease their antihypertensive effect.
  8. Use with cephalosporin class antibiotics may promote bleeding.
  9. Use with diuretics may decrease diuretic effect.

USUAL DOSE

Adults: oral, 100 mg four times a day

Paediatrics (up to age 15): use not recommended.

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